Jehan utilises the most robust and efficient research tools to ensure that the best quality of mesenchymal stem cells are used for tissue regeneration and the treatment of inflammatory diseases.
Jehan has experience and expertise in the immunology of tissue regeneration and the interactions between immune cells or mediators and mesenchymal stem cells. Research has also focused on evaluating the phenotype and repair capacities of stem cells from people suffering from different chronic diseases.
“The optimal tissue regenerative therapies requires careful consideration of the disease microenvironment. We offer specialist testing of both repair and immunomodulatory functions of mesenchymal stem cells in both 2- and 3-dimensional microenvironments”.
Dr Jehan El-Jawhari
Current Research Areas & Activities
The reparative quality of progenitor cells of mesenchyme tissues.
The immunology of regeneration, and crosstalk between immune and stromal mediators.
The biology of mesenchymal stem cells implanted as part of tissue engineered materials.
In vitro Mesenchymal Stem Cell Fitness
Allogenic and Synthetic Scaffolds
El-Sherbiny YM, El-Jawhari JJ, Moseley TA, McGonagle D, Jones E. 2018. T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool. Scientific Reports. 8.1
Fragkakis EM, El-Jawhari JJ, Dunsmuir RA, Millner PA, Rao AS, Henshaw KT, Pountos I, Jones E, Giannoudis PV. 2018. Vertebral body versus iliac crest bone marrow as a source of multipotential stromal cells: Comparison of processing techniques, tri-lineage differentiation and application on a scaffold for spine fusion. PLoS ONE. 13.5
El-Jawhari JJ, Brockett CL, Ktistakis I, Jones E, Giannoudis PV. 2018. The regenerative therapies of the ankle degeneration; A focus on multipotential mesenchymal stromal cell application. Regenerative Medicine. 175-188 13.2
El-Jawhari JJ, Cuthbert R, McGonagle D, Jones E, Giannoudis PV. 2017. CD45lowCD271high Cell Prevalence in Bone Marrow Samples May Provide a Useful Measurement of the Bone Marrow Quality for Cartilage and Bone Regenerative Therapy. Journal of Bone and Joint Surgery – American Volume. 1305-1313 99.15
El-Zayadi AA, Jones EA, Churchman SM, Baboolal TG, Cuthbert RJ, El-Jawhari JJ, Badawy AM, Alase AA, El-Sherbiny YM, McGonagle D. 2017. Interleukin-22 drives the proliferation, migration and osteogenic differentiation of mesenchymal stem cells: a novel cytokine that could contribute to new bone formation in spondyloarthropathies. Rheumatology. 488-493 56.3
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