Samantha McLean

Overview

Dr Samantha McLean is a senior lecturer in microbiology, her research group focusses on the development and evaluation of new antimicrobial technologies that reduce microbial contamination of materials. Her group has expertise including classical microbiology, antimicrobial testing, transcriptomics, standards (BSI, ISO) and the design and use of bespoke models for real-world microbiology application. Samantha is also a member of the British Standards Institute panel working group (products and biofilms).

Contact info

Antimicrobial resistance is a formidable threat, projected to escalate globally into the primary cause of mortality unless swift action is taken. Our interdisciplinary projects are dedicated to developing innovative strategies for infection prevention and control that will slow the spread of resistance and save lives.

Dr Samantha McLean

Current Research Areas & Activities

Biofilm prevention and eradication

Understanding mechanism of action for new antimicrobials

Development of antimicrobial and antibiofilm surfaces

Specialises in

Development of novel antimicrobials

Mechanism of action studies

Antimicrobial activity testing

Bespoke models for biofilm formation

Bacterial transcriptomic analyses

Microbiology testing to recognised standards (BSI, ASTM, ISO etc.)

Bacterial bioreactor studies under steady state

Biofilm characterisation using quantitative and qualitative techniques

In vivo toxicity and infection studies using Galleria mellonella

Selected Publications

Mannix-Fisher, E., and McLean, S., (2021) The antimicrobial activity of silver acetate against Acinetobacter baumannii in a Galleria mellonella infection model. PeerJ 9:e11196 DOI 10.7717/peerj.11196

Varney, A.M., Smitten, K.l., Thomas J.A., and McLean, S. (2020) Transcriptomic Analysis of the Activity and Mechanism of Action of a Ruthenium(II)-Based Antimicrobial That Induces Minimal Evolution of Pathogen Resistance. ACS Pharmacology & Translational Science DOI: 10.1021/acsptsci.0c00159

Wareham, L.K., McLean, S., Begg, R., Rana, N., Ali, S., Kendall, J.J., Sanguinetti, G., Mann, B.E., and Poole, R.K. (2018) The Broad-Spectrum Antimicrobial Potential of [Mn(CO)4(S2CNMe(CH2CO2H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization. Antioxidants and Redox Signalling 28(14), 1286-1308

McLean, S., Begg, R., Jesse, H.E., Mann, B.E., Sanguinetti, G., and Poole, R.K. (2013) Analysis of the bacterial response to Ru(CO)3Cl(glycinate) (CORM-3) and the inactivated compound identifies the role played by the ruthenium compound and reveals sulphur-containing species as a major target of CORM-3 action. Antioxidants and Redox Signalling 17, 1999-2012