COVID-19 Variant Sequencing

Mutations of the SARS-CoV-2 RNA and the potential rise of more infectious or deadly virus variants has increasingly become one of the biggest concerns of the ongoing COVID-19 pandemic.

MTIF have now established COVID-19 Coronavirus ( SARS-CoV-2) rapid whole genome virus sequencing services to assist in variant tracking and COVID-19 surveillance. Utilising Oxford Nanopore Technologies high throughput sequencing technology, namely the GridOn and MinION. The MTIF service has the capacity to sequence up to 1000 samples daily at its Nottingham based facility.

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Rapid Turn Around

 

  • Sequence the SARS-CoV-2 Viral Genome from Various Sample Types
  • Detect Novel SARS-CoV-2 Variants Utilizing COVID-19 ARTIC Network protocols and analysis methods.
  • High throughput processing of samples
  • Nanopore technologies

The Medical Technologies Innovation Facility has under its range of state-of-the-art equipment a suite of Oxford Nanopore instruments capable of both high throughput and long whole genomic sequencing runs. These consist of:

GridION

The on-demand benchtop sequencing, runs up to 5 MinION/Flongle flow cells at any one time. Its system capacity consists of a maximum of 250 GB.

MinION 

The portable DNA/RNA sequencing, has a system capacity, translated into bases per 72 hour run per flow cell (at 450 bps), of 60 Gb. The MinION device and flow cells´ main capabilities of 512 channels and data delivered in real time which can be run for as long or as little as required.